Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

www.nature.com

Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

www.nature.com

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NatureEnglish · 6 months ago

Human TMEFF1 is a restriction factor for herpes simplex virus in the brain - Nature

www.nature.com

A study of two childhood cases of herpes simplex encephalitis shows that TMEFF1 interacts with the HSV-1 cell-surface receptor NECTIN-1, preventing HSV-1 from fusing with the cell membrane and entering cortical neurons.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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